Preservation of the substantia nigra and locus coeruleus in a patient receiving levodopa (2 kg) plus decarboxylase inhibitor over a four-year period

Mov Disord. 1986;1(1):65-8. doi: 10.1002/mds.870010109.


A 72-year-old hypertensive man developed parkinsonism and was treated with Sinemet for 4 years but then died of a bronchial carcinoma. Necropsy revealed cerebrovascular disease and amyloid angiopathy. The substantia nigra and locus coeruleus were normal on light microscopy.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Carbidopa / pharmacology*
  • Drug Combinations / pharmacology
  • Humans
  • Levodopa / pharmacology*
  • Locus Coeruleus / drug effects*
  • Male
  • Parkinson Disease / drug therapy*
  • Substantia Nigra / drug effects*


  • Drug Combinations
  • carbidopa, levodopa drug combination
  • Levodopa
  • Carbidopa