[Examination of Prognostic Factors for Elderly Colon Cancer]

Gan To Kagaku Ryoho. 2021 Dec;48(13):1715-1717.
[Article in Japanese]


Elderly people tend to be in poor general condition and have many comorbidities. It has been reported that these things may be associated with postoperative recurrence and the increase in mortality rate. In order to evaluate their distinctive comorbidity and immunocompetence, we analyzed the covariates including Charlson comorbidity index(CCI), performance status(PS), and immune-nutrient factors. We retrospectively examined 175 cases of radical resection of colon cancer aged 75 years or older performed in our department from January 2000 to December 2014. There were 133/29/11/2 patients for PS 0/1/2/3, respectively. The median CCI was 4.0(range: 1-11). In the multivariate analysis for overall survival(OS), there was a significant difference in PS, BMI, N-factor, venous invasion, pathological stage, neutrophil-to-lymphocyte rate (NLR), lymphocyte-to-monocyte rate(LMR), and modified Glasgow prognostic scale(mGPS). In the multivariate analysis for relapse-free survival(RFS), there was a significant difference in gender, T-factor, N-factor, pathological stage, collected lymph nodes, NLR, LMR, and mGPS. It was suggested that their preoperative general and nutritional conditions can lead to the good oncologic outcomes for the elderly patients in colon cancer.

MeSH terms

  • Aged
  • Colonic Neoplasms* / diagnosis
  • Colonic Neoplasms* / surgery
  • Humans
  • Lymphocytes
  • Neoplasm Recurrence, Local*
  • Neutrophils
  • Prognosis
  • Retrospective Studies