IgA anti-dsDNA antibodies: A neglected serological parameter in systemic lupus erythematosus

Lupus. 2022 Feb;31(2):137-142. doi: 10.1177/09612033221074184. Epub 2022 Jan 20.


Anti-double-stranded DNA (anti-dsDNA) autoantibodies are archetypal biomarkers found in systemic lupus erythematosus (SLE). Although they can exist in any isotype, very little is understood about the IgA isotype for which most of our knowledge is derived from observational studies. This review article summarises our knowledge of this autoantibody isotype to date. Attention will be spent on clinical associations as well as its potential links with lupus nephritis for which there is still some controversy. Further understanding of this serological parameter may facilitate diagnosis, prognosis and treatments of systemic lupus erythematosus patients.

Keywords: IgA; anti-dsDNA; antinuclear antibodies; autoantibodies; systemic lupus erythematosus.

Publication types

  • Review

MeSH terms

  • Antibodies, Antinuclear / blood
  • Autoantibodies
  • Humans
  • Immunoglobulin A / blood
  • Immunoglobulin Isotypes
  • Lupus Erythematosus, Systemic* / diagnosis
  • Lupus Nephritis* / diagnosis


  • Antibodies, Antinuclear
  • Autoantibodies
  • Immunoglobulin A
  • Immunoglobulin Isotypes
  • anti-dsDNA autoantibody