Marine Collagen: A Promising Biomaterial for Wound Healing, Skin Anti-Aging, and Bone Regeneration

Mar Drugs. 2022 Jan 10;20(1):61. doi: 10.3390/md20010061.


Marine organisms harbor numerous bioactive substances that can be utilized in the pharmaceutical and cosmetic industries. Scientific research on various applications of collagen extracted from these organisms has become increasingly prevalent. Marine collagen can be used as a biomaterial because it is water soluble, metabolically compatible, and highly accessible. Upon review of the literature, it is evident that marine collagen is a versatile compound capable of healing skin injuries of varying severity, as well as delaying the natural human aging process. From in vitro to in vivo experiments, collagen has demonstrated its ability to invoke keratinocyte and fibroblast migration as well as vascularization of the skin. Additionally, marine collagen and derivatives have proven beneficial and useful for both osteoporosis and osteoarthritis prevention and treatment. Other bone-related diseases may also be targeted by collagen, as it is capable of increasing bone mineral density, mineral deposition, and importantly, osteoblast maturation and proliferation. In this review, we demonstrate the advantages of marine collagen over land animal sources and the biomedical applications of marine collagen related to bone and skin damage. Finally, some limitations of marine collagen are briefly discussed.

Keywords: antiaging; bone regeneration; collagen peptides; fish collagen; marine collagen; marine sponge; osteoarthritis; osteoporosis; wound healing.

Publication types

  • Review

MeSH terms

  • Animals
  • Aquatic Organisms*
  • Biocompatible Materials*
  • Bone Regeneration
  • Collagen*
  • Skin Aging
  • Wound Healing


  • Biocompatible Materials
  • Collagen