Sustained Response to the Mitogen-Activated Extracellular Kinase Inhibitor Trametinib in a Spindle Cell Sarcoma Harboring a QKI-RAF1 Gene Fusion

JCO Precis Oncol. 2022 Jan:6:e2100303. doi: 10.1200/PO.21.00303.
No abstract available

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Fatal Outcome
  • Female
  • Gene Fusion
  • Humans
  • Proto-Oncogene Proteins c-raf / genetics
  • Pyridones / therapeutic use*
  • Pyrimidinones / therapeutic use*
  • RNA-Binding Proteins / genetics
  • Sarcoma / drug therapy*
  • Sarcoma / genetics
  • Spinal Cord Neoplasms / drug therapy*
  • Spinal Cord Neoplasms / genetics
  • Treatment Outcome

Substances

  • Pyridones
  • Pyrimidinones
  • QKI protein, human
  • RNA-Binding Proteins
  • trametinib
  • Proto-Oncogene Proteins c-raf
  • Raf1 protein, human