Plant-Derived Antioxidants: Significance in Skin Health and the Ageing Process

Int J Mol Sci. 2022 Jan 6;23(2):585. doi: 10.3390/ijms23020585.


Natural substances have traditionally been used in skin care for centuries. There is now an ongoing search for new natural bioactives that not only promote skin health but also protect the skin against various harmful factors, including ultraviolet radiation and free radicals. Free radicals, by disrupting defence and restoration mechanisms, significantly contribute to skin damage and accelerate ageing. Natural compounds present in plants exhibit antioxidant properties and the ability to scavenge free radicals. The increased interest in plant chemistry is linked to the growing interest in plant materials as natural antioxidants. This review focuses on aromatic and medicinal plants as a source of antioxidant substances, such as polyphenols, tocopherols, carotenoids, ascorbic acid, and macromolecules (including polysaccharides and peptides) as well as components of essential oils, and their role in skin health and the ageing process.

Keywords: antioxidants; ascorbic acid; carotenoids; essential oils; macromolecules; natural compounds; phytochemicals; polyphenols; skin; tocopherols.

Publication types

  • Review

MeSH terms

  • Aging*
  • Animals
  • Antioxidants / pharmacology*
  • Ascorbic Acid / pharmacology
  • Carotenoids / pharmacology
  • Humans
  • Oxidative Stress
  • Phytochemicals / pharmacology*
  • Polyphenols / pharmacology
  • Skin / drug effects
  • Skin / metabolism
  • Skin / physiopathology*
  • Tocopherols / pharmacology


  • Antioxidants
  • Phytochemicals
  • Polyphenols
  • Carotenoids
  • Ascorbic Acid
  • Tocopherols