Resveratrol and Immune Cells: A Link to Improve Human Health

Molecules. 2022 Jan 10;27(2):424. doi: 10.3390/molecules27020424.


The use of polyphenols as adjuvants in lowering risk factors for various debilitating diseases has been investigated in recent years due to their possible antioxidant action. Polyphenols represent a fascinating and relatively new subject of research in nutraceuticals and nutrition, with interest rapidly expanding since they can help maintain health by controlling metabolism, weight, chronic diseases, and cell proliferation. Resveratrol is a phenolic compound found mostly in the pulp, peels, seeds, and stems of red grapes. It has a wide variety of biological actions that can be used to prevent the beginning of various diseases or manage their symptoms. Resveratrol can influence multiple inflammatory and non-inflammatory responses, protecting organs and tissues, thanks to its interaction with immune cells and its activity on SIRT1. This compound has anti-inflammatory, antioxidant, anti-apoptotic, neuroprotective, cardioprotective, anticancer, and antiviral properties, making it a potential adjunct to traditional pharmaceutical therapy in public health. This review aims to provide a comprehensive analysis of resveratrol in terms of active biological effects and mechanism of action in modifying the immune cellular response to promote human psychophysical health.

Keywords: SIRT1; immune cells; inflammation; nutraceuticals; resveratrol.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Antiviral Agents / immunology
  • Antiviral Agents / pharmacology*
  • COVID-19 Drug Treatment
  • Dendritic Cells / drug effects
  • Humans
  • Immunity, Cellular / drug effects
  • Macrophages / drug effects
  • Macrophages / immunology
  • Metabolic Syndrome / drug therapy
  • Metabolic Syndrome / immunology
  • Neuroinflammatory Diseases / drug therapy
  • Resveratrol / immunology*
  • Resveratrol / pharmacology*
  • Sirtuin 1 / metabolism


  • Anti-Inflammatory Agents, Non-Steroidal
  • Antiviral Agents
  • Sirtuin 1
  • Resveratrol