Prognostic value of hyperuricemia for patients with sepsis in the intensive care unit

Sci Rep. 2022 Jan 20;12(1):1070. doi: 10.1038/s41598-022-04862-3.


This study evaluated the relationship between hyperuricemia at admission and the clinical prognosis of patients with sepsis. The data were obtained from the Intensive Care Medical Information Database III. The patients were divided into a normal serum uric acid group and a hyperuricemia group. The main outcome was 90-day mortality, and the secondary outcomes were hospital mortality, 30-day mortality, and acute kidney injury. Propensity score matching was used to balance the baseline characteristics of the groups. Our study retrospectively included 954 patients. Before and after propensity score matching, the incidence of AKI, the 30-day and 90-day mortality rates were significantly higher in the hyperuricemia group. Cox regression analysis showed that hyperuricemia was significantly associated with 90-day mortality (HR 1.648, 95% CI 1.215-2.234, p = 0.006), and hyperuricemia was significantly associated with the incidence of AKI (HR 1.773, 95% CI 1.107-2.841, p = 0.017). The Kaplan-Meier survival curve showed that the 90-day survival rate was significantly lower in the hyperuricemia group. In patients with sepsis in the intensive care unit, hyperuricemia was significantly associated with increased risk 90-day all-cause mortality and the incidence of AKI.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Kidney Injury / blood
  • Acute Kidney Injury / epidemiology
  • Acute Kidney Injury / etiology
  • Adult
  • Aged
  • Critical Care
  • Databases, Factual
  • Female
  • Hospital Mortality
  • Hospitalization
  • Humans
  • Hyperuricemia / mortality
  • Hyperuricemia / physiopathology*
  • Incidence
  • Intensive Care Units
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Prognosis
  • Propensity Score
  • Proportional Hazards Models
  • Retrospective Studies
  • Risk Factors
  • Sepsis / complications
  • Sepsis / mortality*
  • Survival Rate
  • Uric Acid / analysis*
  • Uric Acid / blood


  • Uric Acid