Clerodendrum trichotomum extract improves metabolic derangements in high fructose diet-fed rats

Anim Cells Syst (Seoul). 2021 Nov 22;25(6):396-404. doi: 10.1080/19768354.2021.2004221. eCollection 2021.


Clerodendrum trichotomum has been reported to possess beneficial properties for human health, but its effects on metabolic syndrome have not been reported. In this study, we investigated the effect of C. trichotomum leaf extract (CT) on the metabolic derangements induced by a high-fructose (HF) diet. Sprague-Dawley rats were fed with a 46% carbohydrate diet (HC group), 60% high-fructose diet (HF group), or HF diet supplemented with CT (500 mg/kg of body weight/day, CT group) via drinking water for 16 weeks. Results showed that CT alleviated HF diet-induced insulin resistance, dyslipidemia, and hepatic steatosis In liver tissues, CT affected the signaling pathways of AMP-activated protein kinase, peroxisome proliferator-activated receptor α (PPARα), and sterol regulatory element binding protein 1. CT enriched the genes that were mainly involved in cytokine-cytokine receptor interaction, PPAR, PI3K-Akt signaling pathways, and fatty acid metabolism pathway. These results suggest that CT is a promising therapeutic against metabolic disorders.

Keywords: Clerodendrum trichotomum; dyslipidemia; high fructose diet; insulin resistance; metabolic disorders.

Grants and funding

This research was supported by the 2021 Scientific Promotion Program funded by the Jeju National University.