Empagliflozin does not affect left ventricular diastolic function in patients with type 2 diabetes mellitus and coronary artery disease: insight from the EMPA-HEART CardioLink-6 randomized clinical trial

Archana Rai; Kim A Connelly; Subodh Verma; C David Mazer; Hwee Teoh; Ming-Yen Ng; Idan Roifman; Adrian Quan; Marina Pourafkari; Laura Jimenez-Juan; Venkat Ramanan; Yin Ge; Djeven P Deva; Andrew T Yan

doi:10.1007/s00592-021-01823-6

Empagliflozin does not affect left ventricular diastolic function in patients with type 2 diabetes mellitus and coronary artery disease: insight from the EMPA-HEART CardioLink-6 randomized clinical trial

Acta Diabetol. 2022 Apr;59(4):575-578. doi: 10.1007/s00592-021-01823-6. Epub 2022 Jan 21.

Authors

Archana Rai^{1

2}, Kim A Connelly^{2

3

4}, Subodh Verma^{2

3

4

5}, C David Mazer^{2

4

6}, Hwee Teoh^{4

5

7}, Ming-Yen Ng⁸, Idan Roifman^{2

9}, Adrian Quan^{4

5}, Marina Pourafkari^{1

10}, Laura Jimenez-Juan^{1

2}, Venkat Ramanan⁹, Yin Ge^{2

3}, Djeven P Deva^{11

12}, Andrew T Yan^{13

14

15

16}

Affiliations

¹ Division of Cardiology, Department of Medical Imaging, St Michael's Hospital, 30 Bond Street, Rm 6-030D, Toronto, ON, M5B 1W8, Canada.
² University of Toronto, Toronto, Canada.
³ Terrence Donnelly Heart Center, St Michael's Hospital, Toronto, Canada.
⁴ Keenan Research Center, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Canada.
⁵ Division of Cardiac Surgery, St Michael's Hospital, Toronto, Canada.
⁶ Department of Anesthesia, St Michael's Hospital, Toronto, Canada.
⁷ Division of Endocrinology and Metabolism, St Michael's Hospital, Toronto, Canada.
⁸ Department of Diagnostic Radiology, HKU-Shenzhen Hospital and Li Ka Shing Faculty of Medicine, The University of Hong Kong, Shenzhen and Hong Kong SAR, China.
⁹ Schulich Heart Center, Sunnybrook Health Sciences Center, Toronto, Canada.
¹⁰ Queen's University, Kingston, Canada.
¹¹ Division of Cardiology, Department of Medical Imaging, St Michael's Hospital, 30 Bond Street, Rm 6-030D, Toronto, ON, M5B 1W8, Canada. Djeven.Deva@unityhealth.to.
¹² University of Toronto, Toronto, Canada. Djeven.Deva@unityhealth.to.
¹³ Division of Cardiology, Department of Medical Imaging, St Michael's Hospital, 30 Bond Street, Rm 6-030D, Toronto, ON, M5B 1W8, Canada. andrew.yan@unityhealth.to.
¹⁴ University of Toronto, Toronto, Canada. andrew.yan@unityhealth.to.
¹⁵ Terrence Donnelly Heart Center, St Michael's Hospital, Toronto, Canada. andrew.yan@unityhealth.to.
¹⁶ Keenan Research Center, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Canada. andrew.yan@unityhealth.to.

PMID: 35061101
DOI: 10.1007/s00592-021-01823-6

No abstract available

Keywords: Diabetes; Empagliflozin; LV diastolic function; SGLT2 inhibitors.

Publication types

Randomized Controlled Trial

MeSH terms

Benzhydryl Compounds / therapeutic use
Coronary Artery Disease* / complications
Coronary Artery Disease* / drug therapy
Diabetes Mellitus, Type 2* / complications
Diabetes Mellitus, Type 2* / drug therapy
Glucosides / therapeutic use
Humans
Ventricular Function, Left

Substances

Benzhydryl Compounds
Glucosides
empagliflozin