CEUS Versus MRI in Evaluation of the Effect of Microwave Ablation of Breast Cancer

Ultrasound Med Biol. 2022 Apr;48(4):617-625. doi: 10.1016/j.ultrasmedbio.2021.11.012. Epub 2022 Jan 19.


Percutaneous microwave ablation (MWA) is a new minimally invasive technique for breast cancer treatment. The aim of this research was to compare the differences in performance between contrast-enhanced ultrasound (CEUS) and magnetic resonance imaging (MRI) with respect to the curative effect of MWA in the treatment of breast cancer. Between 2015 and 2019, 26 patients with breast cancer underwent ultrasound-guided MWA. All patients underwent both CEUS and MRI within 3 d after ablation. If either of the two imaging modalities revealed suspicious enhancement of the ablation zone and the ultrasound-guided biopsy confirmed residual tumor in the suspicious area, supplementary MWA was applied. The diagnostic efficacy of CEUS and MRI within 3 d after ablation was evaluated based on a >6-mo follow-up of 26 patients. Two cases were diagnosed with residual tumors by ultrasound that were missed by MRI. Three cases were diagnosed with residual tumors by MRI that were missed by CEUS. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of CEUS in the diagnosis of complete ablation were 100%, 40%, 87.5%, 100% and 88.5%, respectively. The sensitivity, specificity, PPV, NPV and accuracy of MRI in the diagnosis of complete ablation were 100%, 60%, 91.3%, 100% and 92.3%, respectively. Within 3 d, both CEUS and MRI can efficiently assess the efficacy of MWA of breast cancer.

Keywords: Ablation techniques; Breast neoplasms; Contrast-enhanced ultrasound; Magnetic resonance imaging.

MeSH terms

  • Breast Neoplasms* / diagnostic imaging
  • Breast Neoplasms* / surgery
  • Contrast Media
  • Female
  • Humans
  • Magnetic Resonance Imaging / methods
  • Microwaves* / therapeutic use
  • Ultrasonography / methods


  • Contrast Media