Hypersensitivity reaction to hyaluronic acid dermal filler after COVID-19 vaccination: A series of cases in São Paulo, Brazil

Int J Infect Dis. 2022 Mar:116:268-270. doi: 10.1016/j.ijid.2022.01.024. Epub 2022 Jan 19.


Brazil ranked second in the world for the number of aesthetic procedures carried out in 2019. Five case reports of delayed hypersensitivity reaction to hyaluronic acid dermal filler after COVID-19 vaccination are presented in this paper. Additional vaccination for new variants, including omicron, will be necessary; therefore, aesthetic professionals should be aware of this possibility and advise patients accordingly.

Keywords: COVID-19 vaccine; aesthetic procedure; delayed hypersensitivity; dermal filler; hyaluronic acid.

Publication types

  • Case Reports

MeSH terms

  • Brazil
  • COVID-19 Vaccines / adverse effects
  • COVID-19* / prevention & control
  • Dermal Fillers* / adverse effects
  • Humans
  • Hyaluronic Acid / adverse effects
  • SARS-CoV-2
  • Vaccination / adverse effects


  • COVID-19 Vaccines
  • Dermal Fillers
  • Hyaluronic Acid