Association of Dyslipidemia and Respiratory Resistance Assessed by the Forced Oscillation Technique in Asthmatic Children

Pakvirin Nanakorn Chanachon; Wanlapa Jotikasthira; Potjanee Kiewngam; Adithep Sawatchai; Watcharoot Kanchongkittiphon; Wiparat Manuyakorn

doi:10.1007/s00408-021-00502-1

Association of Dyslipidemia and Respiratory Resistance Assessed by the Forced Oscillation Technique in Asthmatic Children

Lung. 2022 Feb;200(1):73-82. doi: 10.1007/s00408-021-00502-1. Epub 2022 Jan 22.

Authors

Pakvirin Nanakorn Chanachon¹, Wanlapa Jotikasthira¹, Potjanee Kiewngam¹, Adithep Sawatchai¹, Watcharoot Kanchongkittiphon¹, Wiparat Manuyakorn²

Affiliations

¹ Division of Pediatrics Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama VI Rd, Ratchathewi, Bangkok, 10400, Thailand.
² Division of Pediatrics Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama VI Rd, Ratchathewi, Bangkok, 10400, Thailand. mwiparat@hotmail.com.

PMID: 35064334
DOI: 10.1007/s00408-021-00502-1

Abstract

Purpose: This study aimed to evaluate the associations between dyslipidemia and pulmonary function parameters assessed by spirometry and the forced oscillation technique in asthmatic children.

Methods: Asthmatic children (5-18 years old) had fasting serum lipid profiles including low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C) concentrations, and C-reactive protein (CRP) measured. Pulmonary function tests were assessed by spirometry and the forced oscillation technique (FOT).

Results: One hundred forty-one asthmatic children were enrolled with a mean (SD) age of 11.82 (3.38) years. Eighty-eight (62.4%) children were boys, 64 (45.4%) had dyslipidemia, and 20 (14.2%) were obese. Among the children with dyslipidemia, a high LDL-C concentration (65.6%) was the most common form of dyslipidemia, followed by high TC (57.8%), high TG (35.9%), and low HDL-C concentrations (15.6%). Multivariable analysis showed significant associations between HDL-C concentrations and respiratory resistance at 5 Hz (R₅) and respiratory resistance at 20 Hz (R₂₀), and TC concentrations were modestly associated with reactance at 5 Hz (X₅), the frequency of resonance (Fres), and the area of reactance (ALX). Asthmatic children who had high LDL-C concentrations had a significantly higher expiratory phase R₅, whole breath R₂₀, and expiratory phase R₂₀ than those in children with normal LDL-C concentrations.

Conclusion: This study suggests an association of blood cholesterol, especially HDL-C and LDL-C, and respiratory resistance measured by the FOT, irrespective of the obesity status. An intervention for improving LDL-C and HDL-C concentrations may be beneficial on lung function parameters in asthmatic children.

Clinical trial registration: TCTR20200305005; date of registration: 03-04-2020 (retrospectively registered).

Keywords: Asthma; Children; FEV1; FVC; LDL-C; Oscillometry.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Asthma* / complications
Child
Child, Preschool
Dyslipidemias* / diagnosis
Dyslipidemias* / epidemiology
Female
Forced Expiratory Volume
Humans
Lung
Male
Respiratory Function Tests / methods
Spirometry

Associated data

TCTR/TCTR20200305005