One-year readmission and mortality following ischaemic stroke by diabetes status, sex, and socioeconomic disadvantage: An analysis of 27,802 strokes from 2012 to 2017

J Neurol Sci. 2022 Mar 15:434:120149. doi: 10.1016/j.jns.2022.120149. Epub 2022 Jan 13.

Abstract

Objective: We estimated the 1-year incidence of readmission to hospital and 1-year all-cause mortality following ischaemic stroke (IS), by diabetes status, sex, and socioeconomic disadvantage.

Methods: This study included all individuals aged ≥30 years who were discharged from hospital following an IS between July 2012 and June 2017 in Victoria, Australia (n = 25,421). Individuals were followed from discharge until readmission (for all-causes, cardiovascular readmission, and readmission for IS) or death, censoring at 1-year of follow-up.

Results: The 1-year cumulative incidence of all-cause readmission following an IS was 56.1% (95% CI: 55.5-56.7); 24% of first all-cause admission were attributed to cardiovascular disease. People with diabetes were at an excess risk of all-cause, cardiovascular, and IS readmission following an IS (adjusted sub-HRs: 1.13 [95% CI: 1.09-1.17], 1.14 [1.07-1.21], and 1.17 [1.06-1.29], for people with vs. without diabetes, respectively) and 1-year mortality (adjusted HR: 1.11 [1.03-1.19]). There was no significant difference between men and women in all-cause and cardiovascular readmission risk, while women were at higher risk of IS readmission (sub-HR: 1.10 [1.01-1.21] for women vs. men) and mortality (HR: 1.12 [1.05-1.20]). There was no relationship between socioeconomic disadvantage and risk of cardiovascular or IS readmission, while 1-year mortality risk did increase with increasing socioeconomic disadvantage (HR for most vs. least disadvantaged quintile: 1.15 [1.03-1.27]; ptrend = 0.006), and all-cause readmission risk decreased (sub-HR: 0.94 [0.90-0.99]; ptrend = 0.001).

Conclusions: There is a high risk of readmission following IS. Decreasing the readmission rate will require more complex interventions than solely improving post-discharge cardiovascular management.

Keywords: Healthcare systems; Ischaemic stroke; Social determinants of health; Type 2 diabetes mellitus.

MeSH terms

  • Aftercare
  • Brain Ischemia* / epidemiology
  • Diabetes Mellitus* / epidemiology
  • Female
  • Humans
  • Ischemic Stroke*
  • Male
  • Patient Discharge
  • Patient Readmission
  • Socioeconomic Factors
  • Stroke* / epidemiology