Molecular histocompatibility beyond Tears: The next generation version

Nida Saleem; Rajdeep Das; Anat R Tambur

doi:10.1016/j.humimm.2021.12.005

Molecular histocompatibility beyond Tears: The next generation version

Hum Immunol. 2022 Mar;83(3):233-240. doi: 10.1016/j.humimm.2021.12.005. Epub 2022 Jan 20.

Authors

Nida Saleem¹, Rajdeep Das¹, Anat R Tambur²

Affiliations

¹ Transplant Immunology Laboratory, Comprehensive Transplant Center, Northwestern University, Chicago, IL, USA.
² Transplant Immunology Laboratory, Comprehensive Transplant Center, Northwestern University, Chicago, IL, USA. Electronic address: a-tambur@northwestern.edu.

PMID: 35067388
DOI: 10.1016/j.humimm.2021.12.005

Abstract

Human Leukocyte Antigens (HLA) matching at the serological level used to serve as the measure of histocompatibility between organ donors and recipients. With advancements in HLA typing methods more precise HLA mismatch assessment tools were developed to measure dissimilarities at the molecular level, collectively referred to as Molecular Mismatch load analysis tools. Currently, several software are aimed at deciphering the dissimilarities using somewhat different immunologic rationales. Our goal, in this review is to provide a basic overview of the different computational approaches, provide clinical cases to contextualize concerns regarding the lack of assessment of immunogenicity, and present our personal view regarding the gaps and the needs of our field.

Keywords: Epitope; HLA; Immunogenicity; Molecular Mismatch.

Publication types

Review

MeSH terms

Graft Survival*
HLA Antigens / genetics
Histocompatibility Testing / methods
Histocompatibility*
Humans
Tissue Donors

Substances

HLA Antigens