The Interaction Between N6-Methyladenosine Modification and Non-Coding RNAs in Gastrointestinal Tract Cancers

Lin Yao; Chang-Feng Man; Rong He; Lian He; Jia-Bin Huang; Shou-Yan Xiang; Zhe Dai; Xiao-Yan Wang; Yu Fan

doi:10.3389/fonc.2021.784127

The Interaction Between N⁶-Methyladenosine Modification and Non-Coding RNAs in Gastrointestinal Tract Cancers

Front Oncol. 2022 Jan 7:11:784127. doi: 10.3389/fonc.2021.784127. eCollection 2021.

Authors

Lin Yao¹, Chang-Feng Man¹, Rong He¹, Lian He¹, Jia-Bin Huang¹, Shou-Yan Xiang¹, Zhe Dai¹, Xiao-Yan Wang², Yu Fan¹

Affiliations

¹ Cancer Institute, The Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.
² Digestive Department, The Affiliated Suqian first People's Hospital of Nanjing Medical University, Suqian, China.

Abstract

N⁶-methyladenosine (m⁶A) is the most common epigenetic modification of eukaryotic RNA, which can participate in the growth and development of the body and a variety of physiological and disease processes by affecting the splicing, processing, localization, transport, translation, and degradation of RNA. Increasing evidence shows that non-coding RNAs, particularly microRNA, long non-coding RNA, and circular RNA, can also regulate the RNA m⁶A modification process by affecting the expression of m⁶A-related enzymes. The interaction between m⁶A modification and non-coding RNAs provides a new perspective for the exploration of the potential mechanism of tumor genesis and development. In this review, we summarize the potential mechanisms and effects of m⁶A and non-coding RNAs in gastrointestinal tract cancers.

Keywords: colorectal cancer; gastrointestinal tract cancers; long non-coding RNA (lncRNA); m6A modification; non-coding RNAs (ncRNAs).

Publication types

Review