[Effects of gamma-oryzanol on gastric secretions in rats (author's transl)]

Nihon Yakurigaku Zasshi. 1978 Mar;74(2):285-95. doi: 10.1254/fpj.74.285.
[Article in Japanese]

Abstract

gamma-Oryzanol has been reported to inhibit gastric secretion and experimental ulcers in rats. In this paper, the inhibitory effects of gamma-oryzanol on gastric secretions caused by three stimulants have been compared. gamma-Oryzanol was slightly effective for histamine-stimulated acid secretion, non effective for carbachol-stimulated secretion and significantly inhibited the tetragastrin-stimulated secretion. The effect of gamma-oryzanol on acid secretion stimulated by tetragastrin was prevented by vagotomy but not by splanchnicotomy. It is assumed that the gastric antisecretory effect of gamma-oryzanol is mediated by the vagus nerve which plays a role in the action of gastrin.

MeSH terms

  • Animals
  • Atropine / pharmacology
  • Carbachol / antagonists & inhibitors
  • Gastric Juice / metabolism*
  • Gastrins / antagonists & inhibitors
  • Histamine Antagonists
  • Male
  • Metiamide / pharmacology
  • Pepsin A / metabolism
  • Phenylpropionates / pharmacology*
  • Rats
  • Splanchnic Nerves / surgery
  • Vagotomy

Substances

  • Gastrins
  • Histamine Antagonists
  • Phenylpropionates
  • Metiamide
  • Atropine
  • Carbachol
  • Pepsin A