Endothelial Lipid Metabolism

Cold Spring Harb Perspect Med. 2022 Jul 21;12(6):a041162. doi: 10.1101/cshperspect.a041162.


Endothelial cells (ECs) line all vessels of all vertebrates and are fundamental to organismal metabolism. ECs rely on their metabolism both to transport nutrients in and out of underlying parenchyma, and to support their own cellular activities, including angiogenesis. ECs primarily consume glucose, and much is known of how ECs transport and consume glucose and other carbohydrates. In contrast, how lipids are transported, and the role of lipids in normal EC function, has garnered less attention. We review here recent developments on the role of lipids in endothelial metabolism, with a focus on lipid uptake and transport in quiescent endothelium, and the use of lipid pathways during angiogenesis.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Endothelial Cells*
  • Endothelium, Vascular
  • Glucose
  • Humans
  • Lipid Metabolism*
  • Lipids
  • Neovascularization, Pathologic / metabolism


  • Lipids
  • Glucose