Protein Nanoparticles: Uniting the Power of Proteins with Engineering Design Approaches

Nahal Habibi; Ava Mauser; Yeongun Ko; Joerg Lahann

doi:10.1002/advs.202104012

Protein Nanoparticles: Uniting the Power of Proteins with Engineering Design Approaches

Adv Sci (Weinh). 2022 Mar;9(8):e2104012. doi: 10.1002/advs.202104012. Epub 2022 Jan 25.

Authors

Nahal Habibi¹, Ava Mauser², Yeongun Ko¹, Joerg Lahann³

Affiliations

¹ Biointerfaces Institute, Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
² Biointerfaces Institute, Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
³ Biointerfaces Institute, Departments of Chemical Engineering, Material Science and Engineering, Biomedical Engineering, and Macromolecular Science and Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.

Abstract

Protein nanoparticles, PNPs, have played a long-standing role in food and industrial applications. More recently, their potential in nanomedicine has been more widely pursued. This review summarizes recent trends related to the preparation, application, and chemical construction of nanoparticles that use proteins as major building blocks. A particular focus has been given to emerging trends related to applications in nanomedicine, an area of research where PNPs are poised for major breakthroughs as drug delivery carriers, particle-based therapeutics or for non-viral gene therapy.

Keywords: biomimetic; electrospraying; nanomedicine; protein nanoparticle; self-assembly.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Drug Carriers
Drug Delivery Systems
Nanomedicine*
Nanoparticles*
Proteins

Substances

Drug Carriers
Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding