Pseudomonas aeruginosa efflux pump superfamily (review of literature)

Klin Lab Diagn. 2022 Jan 21;67(1):53-58. doi: 10.51620/0869-2084-2022-67-1-53-58.


The significant increase in the number of antibiotic-resistant microorganisms observed in recent years is a public health problem worldwide. One of the molecular mechanisms for the formation of antimicrobial resistance in bacteria is the presence of efflux pumps. The review presents an analysis of experimental studies related to the study of efflux pumps in clinical strains of Pseudomonas aeruginosa, one of the representatives of hospital pathogens of the ESKAPE group. This review is intended for specialists developing new types of drugs against antibiotic-resistant strains, as well as researchers studying the mechanisms of bacterial resistance to antibiotics, heavy metals, biocides and other antimicrobial factors.

Keywords: ABC; MATE; MFS; PACE; Pseudomonas aeruginosa; RND; SMR; conveyors; efflux pumps; resistance.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Bacteria
  • Drug Resistance, Multiple, Bacterial* / genetics
  • Humans
  • Membrane Transport Proteins / genetics
  • Microbial Sensitivity Tests
  • Pseudomonas aeruginosa* / genetics


  • Anti-Bacterial Agents
  • Membrane Transport Proteins

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