PIWI puts spermatogenesis in its place

Amanda G Charlesworth; Volker Nitschko; Mathias S Renaud; Julie M Claycomb

doi:10.1016/j.devcel.2022.01.001

PIWI puts spermatogenesis in its place

Dev Cell. 2022 Jan 24;57(2):149-151. doi: 10.1016/j.devcel.2022.01.001.

Authors

Amanda G Charlesworth¹, Volker Nitschko¹, Mathias S Renaud¹, Julie M Claycomb²

Affiliations

¹ University of Toronto, Department of Molecular Genetics, Toronto, ON, Canada.
² University of Toronto, Department of Molecular Genetics, Toronto, ON, Canada. Electronic address: julie.claycomb@utoronto.ca.

PMID: 35077678
DOI: 10.1016/j.devcel.2022.01.001

Abstract

In this issue of Developmental Cell, Cornes et al. show that piRNAs initiate transcriptional silencing of spermatogenesis genes in the C. elegans germline via an endogenous nuclear RNAi pathway. This silencing enables a timely transition from spermatogenesis to oogenesis during hermaphrodite development, thus promoting fertility.

Publication types

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MeSH terms

Animals
Caenorhabditis elegans* / genetics
Germ Cells
Male
Oogenesis / genetics
RNA, Small Interfering
Spermatogenesis* / genetics

Substances

RNA, Small Interfering