CSF rhinorrhoeae: significance of the glucose oxidase strip test

Injury. 1987 Sep;18(5):327-8. doi: 10.1016/0020-1383(87)90053-2.


Many authoritative medical textbooks recommended use of glucose oxidase reagent strips to distinguish cerebrospinal fluid rhinorrhoea from clear nasal discharge following head injury. A study of 50 subjects with clear nasal and lacrimal secretions, demonstrated a large proportion of positive results for glucose (44 per cent). Thirteen secretions (26 per cent) contained glucose in a concentration within the normal range for CSF. The recommended use of glucose oxidase test strips for differentiating CSF leakage from other clear nasal secretions is therefore without foundation.

MeSH terms

  • Cerebrospinal Fluid Rhinorrhea / diagnosis*
  • False Positive Reactions
  • Glucose Oxidase*
  • Humans
  • Mucus / analysis
  • Nasal Mucosa / metabolism
  • Reagent Strips*
  • Tears / analysis


  • Reagent Strips
  • Glucose Oxidase