Structural insights into MRGPRX2: A new vision of itch and allergy

J Allergy Clin Immunol. 2022 Apr;149(4):1221-1222. doi: 10.1016/j.jaci.2022.01.017. Epub 2022 Jan 26.

Authors

Anna M Trier¹, Brian S Kim²

Affiliations

¹ Division of Biology and Biomedical Sciences, Washington University School of Medicine, St Louis, Mo.
² Kimberly and Eric J. Waldman Department of Dermatology, Precision Immunology Institute, Friedman Brain Institute, Mark Lebwohl Center for Neuroinflammation and Sensation, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address: itchdoctor@mountsinai.org.

PMID: 35090947
DOI: 10.1016/j.jaci.2022.01.017

No abstract available

Keywords: Allergy; GPCR; MRGPRX2; MRGPRX4; Mrgprs; cryogenic electron microscopy; itch; pruritus; pseudoallergic.

Publication types

Editorial
Research Support, N.I.H., Extramural
Comment

MeSH terms

Cell Degranulation
Humans
Hypersensitivity*
Mast Cells
Nerve Tissue Proteins
Pruritus*
Receptors, G-Protein-Coupled / genetics
Receptors, Neuropeptide / genetics

Substances

MRGPRX2 protein, human
Nerve Tissue Proteins
Receptors, G-Protein-Coupled
Receptors, Neuropeptide

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