It's not what you say, it's how you say it: A retrospective study of the impact of prosody on own-name P300 in comatose patients

Estelle Pruvost-Robieux; Nathalie André-Obadia; Angela Marchi; Tarek Sharshar; Marco Liuni; Martine Gavaret; Jean-Julien Aucouturier

doi:10.1016/j.clinph.2021.12.015

It's not what you say, it's how you say it: A retrospective study of the impact of prosody on own-name P300 in comatose patients

Clin Neurophysiol. 2022 Mar:135:154-161. doi: 10.1016/j.clinph.2021.12.015. Epub 2022 Jan 13.

Authors

Estelle Pruvost-Robieux¹, Nathalie André-Obadia², Angela Marchi³, Tarek Sharshar⁴, Marco Liuni⁵, Martine Gavaret⁶, Jean-Julien Aucouturier⁷

Affiliations

¹ Neurophysiology Department, GHU Paris Psychiatrie et Neurosciences, Sainte Anne Hospital, Paris, France; Université de Paris, Institut Paris Neurosciences et Psychiatrie IPNP (INSERM / Université de Paris), Paris, France; Science and Technology of Music and Sound Lab (IRCAM/CNRS/Sorbonne Université), Paris, France. Electronic address: e.pruvost@ghu-paris.fr.
² Neurophysiology Department, Hôpital Neurologique Pierre Wertheimer, Bron, France.
³ Neurophysiology Department, GHU Paris Psychiatrie et Neurosciences, Sainte Anne Hospital, Paris, France.
⁴ Intensive care unit, GHU Paris Psychiatrie et Neurosciences, Sainte Anne Hospital, Paris, France; Université de Paris, Institut Paris Neurosciences et Psychiatrie IPNP (INSERM / Université de Paris), Paris, France.
⁵ Alta Voce SAS, Houilles, France.
⁶ Neurophysiology Department, GHU Paris Psychiatrie et Neurosciences, Sainte Anne Hospital, Paris, France; Université de Paris, Institut Paris Neurosciences et Psychiatrie IPNP (INSERM / Université de Paris), Paris, France.
⁷ FEMTO-ST Institute (CNRS/Université de Bourgogne Franche Comté), Besançon, France.

PMID: 35093702
DOI: 10.1016/j.clinph.2021.12.015

Abstract

Objective: The acoustic characteristics of stimuli influence the characteristics of the corresponding evoked potentials in healthy subjects. Own-name stimuli are used in clinical practice to assess the level of consciousness in intensive care units. The influence of the acoustic variability of these stimuli has never been evaluated. Here, we explored the influence of this variability on the characteristics of the subject's own name (SON) P300.

Methods: We retrospectively analyzed 251 disorders of consciousness patients from Lyon and Paris Hospitals who underwent an "own-name protocol". A reverse correlation analysis was performed to test for an association between acoustic properties of own-names stimuli used and the characteristics of the P300 wave observed.

Results: Own-names pronounced with increasing pitch prosody showed P300 responses 66 ms earlier than own-names that had a decreasing prosody [IC_95% = 6.36; 125.9 ms].

Conclusions: Speech prosody of the stimuli in the "own name protocol" is associated with latencies differences of the P300 response among patients for whom these responses were observed. Further investigations are needed to confirm these results.

Significance: Speech prosody of the stimuli in the "own name protocol" is a non-negligible parameter, associated with P300 latency differences. Speech prosody should be standardized in SON P300 studies.

Keywords: Acoustic properties; Disorders of consciousness; ERP (Evoked Related Potential); Evoked potentials; Own name protocol; P300 wave.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Coma / diagnosis
Coma / physiopathology*
Electroencephalography / methods*
Electroencephalography / standards
Event-Related Potentials, P300*
Female
Humans
Male
Semantics
Speech Acoustics
Speech Perception*