The present work sought to examine the relationship between stress of coronavirus disease (COVID-19) disease, psychological trauma, and burnout, and whether subjective well-being (SWB), sense of coherence (SOC), and posttraumatic growth (PTG) mediated the relationship between the three constructs in a group of professional healthcare workers engaged on the frontline during the outbreak in Palestine. Results indicated that SWB, SOC, and PTG mediated the association between the stress of COVID, symptoms of trauma, and burnout. The psychological burdens of the ongoing military occupation have been exacerbated by the COVID outbreak, exposing health workers to additional stressors during their work and everyday life. However, a SOC associated with SWB and PTG might be a protective factor for trauma during the pandemic. Implications for health-care providers empowerment are discussed. (PsycInfo Database Record (c) 2022 APA, all rights reserved).