Room Temperature Cu-Catalyzed N-Arylation of Oxazolidinones and Amides with (Hetero)Aryl Iodides

Subhajit Bhunia; Subhadip De; Dawei Ma

doi:10.1021/acs.orglett.2c00122

Room Temperature Cu-Catalyzed N-Arylation of Oxazolidinones and Amides with (Hetero)Aryl Iodides

Org Lett. 2022 Feb 11;24(5):1253-1257. doi: 10.1021/acs.orglett.2c00122. Epub 2022 Jan 31.

Authors

Subhajit Bhunia¹, Subhadip De¹, Dawei Ma¹

Affiliation

¹ State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.

PMID: 35099979
DOI: 10.1021/acs.orglett.2c00122

Abstract

N,N'-Bis(pyridin-2-ylmethyl)oxalamide (BPMO) was found to be an apposite promoter for the Cu-catalyzed N-arylation of oxazolidinones and primary and secondary amides with (hetero)aryl iodides at room temperature. Excellent chemoselectivity reached between aryl iodides and aryl bromides, and a wide range of functional groups tolerated the reaction conditions, which led to the formation of greatly diverse N-arylation products.

Publication types

Research Support, Non-U.S. Gov't