In AF after TAVR, edoxaban was noninferior to VKAs for a composite of adverse events but increased major bleeding

Ann Intern Med. 2022 Feb;175(2):JC22. doi: 10.7326/J21-0014. Epub 2022 Feb 1.

Abstract

Van Mieghem NM, Unverdorben M, Hengstenberg C, et al. Edoxaban versus vitamin K antagonist for atrial fibrillation after TAVR. N Engl J Med. 2021;385:2150-60. 34449183.

Publication types

  • Comment

MeSH terms

  • Anticoagulants / adverse effects
  • Atrial Fibrillation* / drug therapy
  • Atrial Fibrillation* / physiopathology
  • Hemorrhage / chemically induced
  • Humans
  • Pyridines / adverse effects
  • Thiazoles / adverse effects
  • Transcatheter Aortic Valve Replacement* / adverse effects

Substances

  • Anticoagulants
  • Pyridines
  • Thiazoles
  • edoxaban