The roles of HPr and FPr in the utilization of fructose by Escherichia coli

FEBS Lett. 1986 Jan 1;194(1):12-5. doi: 10.1016/0014-5793(86)80042-4.


A mutant impaired in FPr activity was isolated. The altered gene (fpr), which was located near min. 44 on the E. coli genome, was transferred by phage-mediated transduction to appropriate recipients that lack HPr (ptsH), or Enzyme IIman (ptsM), or neither. The rates of growth on fructose of such transductants indicate that phosphate from PEP is transferred predominantly via FPr to fructose that enters the cells by Enzyme IIfru, but that HPr can play a role in transferring phosphate to fructose taken up via Enzyme IIman.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Biological Transport, Active
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism*
  • Chromosomes, Bacterial
  • Escherichia coli / genetics
  • Escherichia coli / growth & development
  • Escherichia coli / metabolism*
  • Escherichia coli Proteins*
  • Fructose / metabolism*
  • Genes
  • Genes, Bacterial
  • Intracellular Signaling Peptides and Proteins
  • Mutation
  • Phosphoenolpyruvate Sugar Phosphotransferase System / genetics
  • Phosphoenolpyruvate Sugar Phosphotransferase System / metabolism*
  • Phosphorylation
  • Protein Kinases


  • Bacterial Proteins
  • Carrier Proteins
  • Escherichia coli Proteins
  • Intracellular Signaling Peptides and Proteins
  • fructose-induced HPr-like protein, bacteria
  • Fructose
  • Protein Kinases
  • fruB protein, E coli
  • Phosphoenolpyruvate Sugar Phosphotransferase System
  • phosphocarrier protein HPr