Management of orofacial lesions with antimicrobial photodynamic therapy and photobiomodulation protocols in patients with COVID-19: A multicenter case series

Paula Sachet; Breno Amaral Rocha; Fabianne Soares Lima; Marlus da Silva Pedrosa; André Guollo; Mário Rodrigues de Melo Filho; Martinho Campolina Rebello Horta; Alyne Simões

doi:10.1016/j.pdpdt.2022.102743

Management of orofacial lesions with antimicrobial photodynamic therapy and photobiomodulation protocols in patients with COVID-19: A multicenter case series

Photodiagnosis Photodyn Ther. 2022 Jun:38:102743. doi: 10.1016/j.pdpdt.2022.102743. Epub 2022 Jan 31.

Authors

Paula Sachet¹, Breno Amaral Rocha², Fabianne Soares Lima³, Marlus da Silva Pedrosa³, André Guollo⁴, Mário Rodrigues de Melo Filho⁵, Martinho Campolina Rebello Horta⁶, Alyne Simões⁷

Affiliations

¹ Hospital Regional do Oeste, Chapecó, SC, Brazil; Department of Biomaterials and Oral Biology, School of Dentistry, University of São Paulo, Av. Prof. Lineu Prestes, 2227 - Cidade Universitária, São Paulo, SP 05508-900, Brazil.
² Graduate Program in Dentistry, School of Dentistry, Pontifícia Universidade Católica de Minas Gerais (PUC Minas), Belo Horizonte, Minas Gerais, Brazil; Department of Dentistry, FIPMoc University Center (UNIFIPMoc), Montes Claros, Minas Gerais, Brazil.
³ Department of Biomaterials and Oral Biology, School of Dentistry, University of São Paulo, Av. Prof. Lineu Prestes, 2227 - Cidade Universitária, São Paulo, SP 05508-900, Brazil.
⁴ Hospital Unimed, Chapecó, SC, Brazil.
⁵ Department of Dentistry, State University of Montes Claros (Unimontes), Montes Claros, Minas Gerais, Brazil.
⁶ Graduate Program in Dentistry, School of Dentistry, Pontifícia Universidade Católica de Minas Gerais (PUC Minas), Belo Horizonte, Minas Gerais, Brazil.
⁷ Department of Biomaterials and Oral Biology, School of Dentistry, University of São Paulo, Av. Prof. Lineu Prestes, 2227 - Cidade Universitária, São Paulo, SP 05508-900, Brazil. Electronic address: lysimoes@usp.br.

Abstract

Several oral lesions related to COVID-19 have been described in the scientific literature. The COVID-19 pandemic highlighs importance of supportive protocols, which can reduce the inflammation and aid in tissue repair in severe cases. Photobiomodulation therapy (PBMT) alone or in combination with antimicrobial photodynamic therapy (aPDT) can be used to manage orofacial lesions in confirmed cases of COVID-19. Here, we sought to describe the clinical presentation and specificities of three cases in which aPDT and PBMT were used to manage orofacial lesions in patients with COVID-19. The laser protocols were effective with improvement of the orofacial lesions within a few days.

Keywords: COVID-19; Orofacial manifestations; Photobiomodulation therapy; Photodynamic therapy; SARS-CoV-2.

MeSH terms

Anti-Bacterial Agents / therapeutic use
Anti-Infective Agents* / therapeutic use
COVID-19*
Humans
Low-Level Light Therapy* / methods
Multicenter Studies as Topic
Pandemics
Photochemotherapy* / methods
Photosensitizing Agents / therapeutic use
SARS-CoV-2

Substances

Anti-Bacterial Agents
Anti-Infective Agents
Photosensitizing Agents