Management of orofacial lesions with antimicrobial photodynamic therapy and photobiomodulation protocols in patients with COVID-19: A multicenter case series

Photodiagnosis Photodyn Ther. 2022 Jun:38:102743. doi: 10.1016/j.pdpdt.2022.102743. Epub 2022 Jan 31.


Several oral lesions related to COVID-19 have been described in the scientific literature. The COVID-19 pandemic highlighs importance of supportive protocols, which can reduce the inflammation and aid in tissue repair in severe cases. Photobiomodulation therapy (PBMT) alone or in combination with antimicrobial photodynamic therapy (aPDT) can be used to manage orofacial lesions in confirmed cases of COVID-19. Here, we sought to describe the clinical presentation and specificities of three cases in which aPDT and PBMT were used to manage orofacial lesions in patients with COVID-19. The laser protocols were effective with improvement of the orofacial lesions within a few days.

Keywords: COVID-19; Orofacial manifestations; Photobiomodulation therapy; Photodynamic therapy; SARS-CoV-2.

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Anti-Infective Agents* / therapeutic use
  • COVID-19*
  • Humans
  • Low-Level Light Therapy* / methods
  • Multicenter Studies as Topic
  • Pandemics
  • Photochemotherapy* / methods
  • Photosensitizing Agents / therapeutic use
  • SARS-CoV-2


  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Photosensitizing Agents