Alprazolam as an adjunct to propranolol in anxious outpatients with stable angina pectoris

J Clin Psychiatry. 1986 Jan;47(1):8-11.


A double-blind crossover comparison is reported of the effects of alprazolam and placebo on anxiety and angina in 27 ambulatory outpatients with angina pectoris stabilized on propranolol. Alprazolam was shown to be a safe treatment when combined with propranolol in these patients. Patients receiving alprazolam with propranolol reported more improvement on their targeted symptoms than did patients receiving placebo with propranolol. The side effect most often reported was moderate drowsiness or sedation; no unusual side effects emerged. There was no evidence that alprazolam compromised the patients' response to propranolol.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Alprazolam
  • Angina Pectoris / complications
  • Angina Pectoris / drug therapy*
  • Anxiety / complications
  • Anxiety / drug therapy*
  • Benzodiazepines / adverse effects
  • Benzodiazepines / therapeutic use*
  • Clinical Trials as Topic
  • Double-Blind Method
  • Drug Therapy, Combination
  • Humans
  • Middle Aged
  • Propranolol / therapeutic use*
  • Sleep Stages / drug effects


  • Benzodiazepines
  • Propranolol
  • Alprazolam