Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Feb 1;327(5):483-485.
doi: 10.1001/jama.2021.23652.

Trends in Use of Melatonin Supplements Among US Adults, 1999-2018

Jingen Li  1 , Virend K Somers  2 , Hao Xu  3 , Francisco Lopez-Jimenez  2 , Naima Covassin  2
Affiliations

Trends in Use of Melatonin Supplements Among US Adults, 1999-2018

Jingen Li et al. JAMA. .

Abstract

This study examines reported prevalence and trends in use of melatonin supplements among US adults from 1999 through 2018.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest Disclosures: Dr Somers reported having served as a consultant for Respicardia, Baker Tilly, Bayer, and Jazz Pharmaceuticals and serving on the Sleep Number Research Advisory Board. No other disclosures were reported.

Figures

Figure.
Figure.. Trends in Reported Weighted Prevalence of Overall Melatonin Use and Melatonin Use Greater Than 5 mg/d Among US Adults
The unweighted numbers of participants using melatonin overall and using >5 mg/d of melatonin were 296 and 39, respectively. Shaded areas indicate 95% confidence intervals. P values for linear and quadratic trends were calculated using linear regression modeling survey cycle as a continuous variable. For overall use, linear P = .004 and quadratic P < .001; for use greater than 5 mg/d, linear P = .005 and quadratic P = .04. Prevalence trends for melatonin use greater than 5 mg/d were estimated from the 2005-2006 to 2017-2018 cycles.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Auger RR, Burgess HJ, Emens JS, Deriy LV, Thomas SM, Sharkey KM. Clinical practice guideline for the treatment of intrinsic circadian rhythm sleep-wake disorders: advanced sleep-wake phase disorder (ASWPD), delayed sleep-wake phase disorder (DSWPD), non-24-hour sleep-wake rhythm disorder (N24SWD), and irregular sleep-wake rhythm disorder (ISWRD): an update for 2015: an American Academy of Sleep Medicine clinical practice guideline. J Clin Sleep Med. 2015;11(10):1199-1236. doi:10.5664/jcsm.5100 - DOI - PMC - PubMed
    1. Sateia MJ, Buysse DJ, Krystal AD, Neubauer DN, Heald JL. Clinical practice guideline for the pharmacologic treatment of chronic insomnia in adults: an American Academy of Sleep Medicine clinical practice guideline. J Clin Sleep Med. 2017;13(2):307-349. doi:10.5664/jcsm.6470 - DOI - PMC - PubMed
    1. Morvaridzadeh M, Sadeghi E, Agah S, et al. . Effect of melatonin supplementation on oxidative stress parameters: a systematic review and meta-analysis. Pharmacol Res. 2020;161:105210. doi:10.1016/j.phrs.2020.105210 - DOI - PubMed
    1. Tordjman S, Chokron S, Delorme R, et al. . Melatonin: pharmacology, functions and therapeutic benefits. Curr Neuropharmacol. 2017;15(3):434-443. doi:10.2174/1570159X14666161228122115 - DOI - PMC - PubMed
    1. Besag FMC, Vasey MJ, Lao KSJ, Wong ICK. Adverse events associated with melatonin for the treatment of primary or secondary sleep disorders: a systematic review. CNS Drugs. 2019;33(12):1167-1186. doi:10.1007/s40263-019-00680-w - DOI - PubMed

Publication types