Ischemic heart disease and its risk factors in patients with diabetic foot ulcers: A systematic review and meta-analysis

Diabetes Metab Syndr. 2022 Feb;16(2):102414. doi: 10.1016/j.dsx.2022.102414. Epub 2022 Jan 25.


Aims: There is limited literature on IHD in DFU patients. This review aimed to determine the prevalence of and risk factors of IHD in patients with DFUs.

Methods: Seven electronic databases were searched from inception to April 2021.

Results: The prevalence of IHD in DFU patients ranged from 6.83% to 60.61% with a pooled mean of 25.85% (95% CI, 24.28%-27.32%). Several risk factors were identified including hypertension, male gender, smoking, and peripheral vascular disease.

Conclusion: We identified multiple risk factors for IHD requiring early interventions to increase long-term quality of life for patients with DFUs.

Keywords: Diabetic foot ulcer; Ischemic heart disease; Prevalence; Risk factors.

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Diabetes Mellitus*
  • Diabetic Foot* / epidemiology
  • Diabetic Foot* / etiology
  • Humans
  • Male
  • Myocardial Ischemia*
  • Peripheral Vascular Diseases*
  • Quality of Life
  • Risk Factors