Cefazolin-induced pseudomembranous colitis resulting in perforation of the sigmoid colon

Dis Colon Rectum. 1986 Feb;29(2):140-3. doi: 10.1007/BF02555402.


The seventh case of probable cefazolin-induced pseudomembranous colitis is reported. Perforation of the colon necessitated sigmoid resection. The postoperative course was protracted, and illustrates the difficulty of managing advanced pseudomembranous colitis when the oral route of antibiotic administration is not available. Although rare, pseudomembranous colitis related to cefazolin administration is a potentially fatal complication. The routine use of prophylactic antibiotics must be weighed against this possibility.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Cefazolin / adverse effects*
  • Cefazolin / therapeutic use
  • Colectomy
  • Enterocolitis, Pseudomembranous / chemically induced*
  • Enterocolitis, Pseudomembranous / complications
  • Enterocolitis, Pseudomembranous / diagnostic imaging
  • Enterocolitis, Pseudomembranous / surgery
  • Female
  • Humans
  • Intestinal Perforation / diagnostic imaging
  • Intestinal Perforation / etiology*
  • Intestinal Perforation / surgery
  • Premedication
  • Sigmoid Diseases / diagnostic imaging
  • Sigmoid Diseases / etiology*
  • Sigmoid Diseases / surgery
  • Tomography, X-Ray Computed


  • Cefazolin