Forgetting in obesity: The pregnenolone link

Luigi Bellocchio; Giovanni Marsicano

doi:10.1016/j.cmet.2022.01.006

Forgetting in obesity: The pregnenolone link

Cell Metab. 2022 Feb 1;34(2):187-188. doi: 10.1016/j.cmet.2022.01.006.

Authors

Luigi Bellocchio¹, Giovanni Marsicano²

Affiliations

¹ INSERM, U1215 NeuroCentre Magendie, Endocannabinoids and Neuroadaptation, Bordeaux, France; University of Bordeaux, Bordeaux, France. Electronic address: luigi.bellocchio@inserm.fr.
² INSERM, U1215 NeuroCentre Magendie, Endocannabinoids and Neuroadaptation, Bordeaux, France; University of Bordeaux, Bordeaux, France. Electronic address: giovanni.marsicano@inserm.fr.

PMID: 35108507
DOI: 10.1016/j.cmet.2022.01.006

Abstract

Cognitive dysfunction is often diagnosed in people with obesity and associated metabolic disorders. In the latest issue of Cell Metabolism, Ramírez et al. highlight an impaired production of the neurosteroid pregnenolone in the hypothalamus as a mechanism for obesity-induced cognitive impairment in both rodent models and patients with obesity.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Humans
Hypothalamus*
Obesity / complications
Pregnenolone*

Substances

Pregnenolone