Primary Sclerosing Cholangitis and Autoimmune Hepatitis Overlapping Syndrome Complicated by Ulcerative Colitis

Intern Med. 2022 Aug 15;61(16):2471-2475. doi: 10.2169/internalmedicine.8866-21. Epub 2022 Feb 1.


The case of a 28-year-old man who had primary sclerosing cholangitis and autoimmune hepatitis overlapping syndrome (PSC-AIH OS) complicated by ulcerative colitis (UC) is reported. First, he was diagnosed with PSC complicated by UC and initially treated with ursodeoxycholic acid and mesalazine. Twenty-four months later, liver damage reappeared, and we performed a liver biopsy, which showed the features of AIH. We eventually diagnosed him with PSC-AIH OS complicated by UC. If liver damage worsens in PSC patients, PSC-AIH OS should be considered. The optimum management approach for PSC-AIH OS should be established.

Keywords: autoimmune hepatitis; primary sclerosing cholangitis; ulcerative colitis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biopsy
  • Cholangitis, Sclerosing* / complications
  • Cholangitis, Sclerosing* / diagnosis
  • Cholangitis, Sclerosing* / pathology
  • Colitis, Ulcerative* / complications
  • Colitis, Ulcerative* / diagnosis
  • Connective Tissue Diseases* / complications
  • Hepatitis, Autoimmune* / complications
  • Hepatitis, Autoimmune* / diagnosis
  • Hepatitis, Autoimmune* / drug therapy
  • Humans
  • Male
  • Syndrome
  • Ursodeoxycholic Acid / therapeutic use


  • Ursodeoxycholic Acid