Treatment of Bilateral Endogenous Aspergillus Endophthalmitis with Multiple Intravitreal Voriconazole Injections with Good Visual Outcome

Inas F Aboobakar; Sally S Ong; Akosua Nti; Kim Jiramongkolchai; J Fernando Arevalo

doi:10.1159/000520819

Treatment of Bilateral Endogenous Aspergillus Endophthalmitis with Multiple Intravitreal Voriconazole Injections with Good Visual Outcome

Case Rep Ophthalmol. 2021 Dec 30;12(3):1002-1007. doi: 10.1159/000520819. eCollection 2021 Sep-Dec.

Authors

Inas F Aboobakar¹, Sally S Ong¹, Akosua Nti¹, Kim Jiramongkolchai¹, J Fernando Arevalo¹

Affiliation

¹ Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland, USA.

Abstract

Endogenous endophthalmitis caused by Aspergillus species tends to be very aggressive, often leading to devastating visual outcomes. Historically, intravitreal amphotericin injections have played a central role in management, but with variable visual outcomes and a risk of toxicity. Limited reports suggest that use of intravitreal voriconazole is a safe and efficacious alternative, though these cases were treated with only few intravitreal injections. Here, we report a case of bilateral endogenous Aspergillus endophthalmitis treated with 8 intravitreal voriconazole injections in the right eye and 11 in the left eye with good best-corrected final visual outcome (20/50 right eye and 20/40 left eye).

Keywords: Aspergillus; Endogenous endophthalmitis; Intravitreal voriconazole.

Publication types

Case Reports