Expression of the c-myb proto-oncogene during cellular proliferation

Nature. 1986 Jan 30-Feb 5;319(6052):374-80. doi: 10.1038/319374a0.


In several cell types, messenger RNA levels of the nuclear proto-oncogene c-myb vary as a function of cellular proliferation; a transient increase in c-myb steady-state mRNA, mediated by post-transcriptional mechanisms, occurs during cell-cycle progression. In contrast, both quiescent and proliferating immature thymocytes contain exceptionally high levels of c-myb mRNA as a consequence of increased c-myb transcription.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Bursa of Fabricius / cytology
  • Cell Cycle*
  • Cells, Cultured
  • Chickens
  • Gene Expression Regulation
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogenes*
  • RNA, Messenger / genetics
  • Thymus Gland / cytology
  • Transcription, Genetic


  • Proto-Oncogene Proteins
  • RNA, Messenger