1 From the Division of Pediatric Anesthesiology, Department of Anesthesiology, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA (ARLH), Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden (ARLH) and Division of Pediatric Anesthesiology, Department of Anesthesiology and Perioperative Medicine, Tufts Medical Center, Boston, Massachusetts, USA (GF, AK).