Literature review of the mechanisms of acute kidney injury secondary to acute liver injury

Esther Platt; Enriko Klootwijk; Alan Salama; Brian Davidson; Francis Robertson

doi:10.5527/wjn.v11.i1.13

Literature review of the mechanisms of acute kidney injury secondary to acute liver injury

World J Nephrol. 2022 Jan 25;11(1):13-29. doi: 10.5527/wjn.v11.i1.13.

Authors

Esther Platt¹, Enriko Klootwijk², Alan Salama², Brian Davidson³, Francis Robertson³

Affiliations

¹ Division of Surgery and Interventional Science, University College London, London NW3 2QG, United Kingdom. esther.platt.20@ucl.ac.uk.
² Department of Renal Medicine, University College London, London NW3 2PF, United Kingdom.
³ Division of Surgery and Interventional Science, University College London, London NW3 2QG, United Kingdom.

Abstract

People exposed to liver ischaemia reperfusion (IR) injury often develop acute kidney injury and the combination is associated with significant morbidity and mortality. Molecular mediators released by the liver in response to IR injury are the likely cause of acute kidney injury (AKI) in this setting, but the mediators have not yet been identified. Identifying the mechanism of injury will allow the identification of therapeutic targets which may modulate both liver IR injury and AKI following liver IR injury.

Keywords: Acute kidney injury; Ischaemia-reperfusion injury; Liver; Liver failure; Liver transplantation.

Publication types

Review