Pilomatrical Acanthoma: An Extremely Rare Intraepidermal Variant of Pilomatricoma

Am J Dermatopathol. 2022 Jun 1;44(6):433-436. doi: 10.1097/DAD.0000000000002147. Epub 2022 Feb 2.

Abstract

Pilomatrical differentiation can be observed in a variety of benign and malignant tumors, with the most common prototype being pilomatricoma. Pilomatricoma often presents in the deep dermis or subcutis, and the sole involvement of epidermis is extremely rare. In our current case series, specimens from 5 patients were included with an average age of 68 years. All lesions presented as solitary verrucous or keratotic papules on the extremities, with 1 lesion having a prominent horn. All lesions have a variable mixture of basaloid matrical cells and shadow cells, and all lesions express β-catenin (strong nuclear and cytoplasmic), lymphoid enhancer-binding factor 1 within the matrical component, and pleckstrin homology-like domain family A member 1. The histomorphology and immunoprofile of all lesions are of pilomatrical differentiation, confined to the level of the epidermis. Based on these findings and analogous to the terminology used for other benign intraepidermal proliferations (hidroacanthoma simplex and epidermolytic acanthoma), we propose the term "pilomatrical acanthoma" for these rare lesions.

MeSH terms

  • Acanthoma*
  • Aged
  • Hair Diseases* / pathology
  • Hair Diseases* / surgery
  • Humans
  • Pilomatrixoma* / pathology
  • Pilomatrixoma* / surgery
  • Skin Neoplasms* / pathology
  • Sweat Gland Neoplasms*