Cut out that YAPping: Mechanisms to reduce scar formation

Valerie Horsley

doi:10.1016/j.stem.2022.01.005

Cut out that YAPping: Mechanisms to reduce scar formation

Cell Stem Cell. 2022 Feb 3;29(2):179-181. doi: 10.1016/j.stem.2022.01.005.

Author

Valerie Horsley¹

Affiliation

¹ Department of Molecular, Cell, and Developmental Biology, Yale University, New Haven, CT, USA; Department of Dermatology, Yale School of Medicine, Yale University, New Haven, CT, USA. Electronic address: valerie.horsley@yale.edu.

PMID: 35120615
DOI: 10.1016/j.stem.2022.01.005

Abstract

Tissue repair in adult mammals lacks the regenerative ability of many tissues in other adult organisms like axolotl and newts. In this issue of Cell Stem Cell, Mascharak et al. use multi-omics approaches to identify an essential role for the transcription factor Trps1 in Yap-inhibited fibroblasts' tissue regenerative responses in murine skin.

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MeSH terms

Animals
Cicatrix* / pathology
Fibroblasts / pathology
Mammals
Mice
Skin / pathology
Transcription Factors
Wound Healing* / physiology

Substances

Transcription Factors