Alternative 5' exons in c-abl mRNA

Cell. 1986 Feb 28;44(4):577-86. doi: 10.1016/0092-8674(86)90267-9.

Abstract

The cellular abl proto-oncogene encodes a protein-tyrosine kinase and is expressed in many cell types in two or three mRNA size species. Four types of mouse c-abl cDNAs have been cloned from 70Z/3 lymphoid cells that have different 5' sequences encoding predicted N-terminal regions of 20-45 amino acids. One of the four cDNAs has a predicted N-terminal sequence of met-gly-gln in common with the gag N terminus of v-abl. The 5' heterogeneity appears to be generated by alternative addition of 5' exons onto a common set of 3' exons. Alternative splicing occurs at the same site at which bcr sequences join to abl sequences in the Philadelphia chromosome translocation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • Gene Expression Regulation
  • Genes
  • Mice
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogenes*
  • RNA Processing, Post-Transcriptional
  • RNA Splicing
  • RNA, Messenger / genetics
  • Tissue Distribution

Substances

  • Proto-Oncogene Proteins
  • RNA, Messenger

Associated data

  • GENBANK/K03228
  • GENBANK/M12263
  • GENBANK/M12264
  • GENBANK/M12265
  • GENBANK/M12266