Multi-omics analysis reveals the mechanisms of action and therapeutic regimens of traditional Chinese medicine, Bufei Jianpi granules: Implication for COPD drug discovery

Hechen Wang; Yuanyuan Hou; Xiaoyao Ma; Linlin Cui; Yongrui Bao; Yang Xie; Suyun Li; Xiansheng Meng; Jiansheng Li; Gang Bai

doi:10.1016/j.phymed.2022.153963

Multi-omics analysis reveals the mechanisms of action and therapeutic regimens of traditional Chinese medicine, Bufei Jianpi granules: Implication for COPD drug discovery

Phytomedicine. 2022 Apr:98:153963. doi: 10.1016/j.phymed.2022.153963. Epub 2022 Jan 29.

Authors

Hechen Wang¹, Yuanyuan Hou¹, Xiaoyao Ma¹, Linlin Cui², Yongrui Bao², Yang Xie³, Suyun Li⁴, Xiansheng Meng⁵, Jiansheng Li⁶, Gang Bai⁷

Affiliations

¹ State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300353, China.
² College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China.
³ The Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450000, China.
⁴ The Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450000, China; Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases co-constructed by Henan province & Education Ministry of P.R., China, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
⁵ College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China. Electronic address: mxsvvv@126.com.
⁶ The Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450000, China; Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases co-constructed by Henan province & Education Ministry of P.R., China, Henan University of Chinese Medicine, Zhengzhou, 450046, China. Electronic address: lijs8@163.com.
⁷ State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300353, China. Electronic address: gangbai@nankai.edu.cn.

PMID: 35121390
DOI: 10.1016/j.phymed.2022.153963

Abstract

Background: Chronic Obstructive Pulmonary Disease (COPD) is a serious public health challenge in the world. According to the treatment instructions by Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2020, bronchiectasis combine with inhaled corticosteroids and long-acting anti-muscarinic agents were recommended as the main prescription. However, this symptomatic treatment still has ineluctable limits because it ignored the most pathogenesis mechanism of COPD. As an alternative traditional Chinese medicine (TCM) for COPD, Bufei Jianpi granules (BJG) can reduce the frequency and duration of acute exacerbation in COPD patients and improve their quality of life. The evidence demonstrated BJG acts as therapeutics that retarding the airway remodeling process, eliminating phlegm, thrombolysis and improving mitochondrial function. However, the detailed molecular mechanism is still urgently revealed.

Purpuse: In this study, we aim to find out the active pharmacodynamic ingredients and reveal the treatment mechanism of active pharmacodynamic ingredients.

Methods: Based on the pharmacodynamic evaluation and chemomic profiling of BJG in COPD rats, an integrated multi-omics analysis was performed, including molecular networking, metabonomics, proteomics and bioinformatics. Moreover, focus on the active compounds, we verified the molecular core mechanism by molecular biology methods.

Results: Pachymic acid, shionone, peiminine and astragaloside A was verified as therapeutic agents for improving the condition of COPD by acting on the EGFR, ERK1, PAI-1 and p53 target, respectively.

Conclusion: In this study, our findings indicated that some compounds in BJG alleviates the pathological process of COPD, which is related to regulating lung function, mucus production, pulmonary embolism and energy metabolism and this will be a benefit complementary to GOLD guidelines.

Keywords: Airway remodeling; COPD; Lnergy metabolism; Lung thromboclasis; Mucin; Multiomics analysis.