Decision tree classification of cognitive functions with D2 receptor occupancy and illness severity in late-life schizophrenia

Keisuke Kusudo; Ryo Ochi; Shinichiro Nakajima; Takefumi Suzuki; David Mamo; Fernando Caravaggio; Wanna Mar; Philip Gerretsen; Masaru Mimura; Bruce G Pollock; Benoit H Mulsant; Ariel Graff-Guerrero; Tarek K Rajji; Hiroyuki Uchida

doi:10.1016/j.schres.2022.01.044

Decision tree classification of cognitive functions with D₂ receptor occupancy and illness severity in late-life schizophrenia

Schizophr Res. 2022 Mar:241:113-115. doi: 10.1016/j.schres.2022.01.044. Epub 2022 Feb 1.

Authors

Affiliations

¹ Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
² Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan; Brain Health Imaging Centre-Multimodal Imaging Group in Geriatrics and Schizophrenia, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
³ Department of Neuropsychiatry and Clinical Ethics, University of Yamanashi, Yamanashi, Japan.
⁴ Departments of Psychiatry & Gerontology, University of Malta, Msida, Malta.
⁵ Brain Health Imaging Centre-Multimodal Imaging Group in Geriatrics and Schizophrenia, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
⁶ Brain Health Imaging Centre-Multimodal Imaging Group in Geriatrics and Schizophrenia, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Adult Neurodevelopmental and Geriatric Psychiatry Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
⁷ Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Adult Neurodevelopmental and Geriatric Psychiatry Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
⁸ Brain Health Imaging Centre-Multimodal Imaging Group in Geriatrics and Schizophrenia, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Adult Neurodevelopmental and Geriatric Psychiatry Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. Electronic address: ariel.graff@camh.ca.
⁹ Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Adult Neurodevelopmental and Geriatric Psychiatry Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Toronto Dementia Research Alliance, University of Toronto, Toronto, Ontario, Canada.
¹⁰ Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan; Adult Neurodevelopmental and Geriatric Psychiatry Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

PMID: 35121434
DOI: 10.1016/j.schres.2022.01.044

No abstract available

Keywords: Antipsychotics; Cognition; Dopamine D(2) receptor; Machine learning; Schizophrenia; [(11)C]Raclopride.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Antipsychotic Agents* / therapeutic use
Cognition
Decision Trees
Humans
Patient Acuity
Positron-Emission Tomography
Raclopride / therapeutic use
Schizophrenia* / complications
Schizophrenia* / drug therapy

Substances

Antipsychotic Agents
Raclopride

Publication types

MeSH terms

Substances

Grants and funding