Effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. VII. Mortality and selected nonfatal events with insulin treatment

JAMA. 1978 Jul 7;240(1):37-42.


The University Group Diabetes Program is a long-term prospective clinical trial designed to evaluate the effects of various hypoglycemic agents on vascular complications in patients with asymptomatic adult-onset diabetes. Mortality and blood glucose levels were determined as well as certain nonfatal events for patients assigned to diet alone or to either of two insulin treatment regimens. Lower levels of blood glucose with mean values close to normoglycemia were achieved in the treatment group in which the insulin dosage was adjusted to achieve normoglycemia compared with the levels achieved in patients treated with diet alone or with a fixed dose of insulin. In spite of differences in blood glucose levels among the treatment groups, there were only minor differences in the occurrence of fatal or nonfatal events.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Blood Glucose / analysis*
  • Clinical Trials as Topic
  • Diabetes Complications
  • Diabetes Mellitus / diet therapy
  • Diabetes Mellitus / drug therapy*
  • Diabetes Mellitus / mortality
  • Diabetic Angiopathies / epidemiology*
  • Follow-Up Studies
  • Glucose Tolerance Test
  • Humans
  • Hypoglycemia / chemically induced
  • Insulin / administration & dosage
  • Insulin / adverse effects
  • Insulin / pharmacology
  • Insulin / therapeutic use*
  • Prospective Studies
  • Risk


  • Blood Glucose
  • Insulin