Emerg Med Clin North Am. 1986 Feb;4(1):175-83.


The clinical significance of chloride should place this ion on an equal basis with sodium, potassium, and bicarbonate in the evaluation of body fluid or acid-base status. The rationale for ordering serum chloride determinations includes basically all the indications for requesting the other three electrolytes, particularly when there is concern about a patient's fluid, electrolyte, and/or acid-base status.

Publication types

  • Review

MeSH terms

  • Acid-Base Equilibrium
  • Acidosis / diagnosis
  • Alkalosis / diagnosis
  • Chlorides / blood*
  • Diagnosis, Differential
  • Emergencies
  • Extracellular Space / physiology
  • Humans
  • Hypernatremia / diagnosis
  • Hyponatremia / diagnosis
  • Methods
  • Sodium Chloride / blood


  • Chlorides
  • Sodium Chloride