Triglyceride-lowering effect of dietary vitamin E in streptozocin-induced diabetic rats. Increased lipoprotein lipase activity in livers of diabetic rats fed high dietary vitamin E

Diabetes. 1986 Mar;35(3):278-81. doi: 10.2337/diab.35.3.278.

Abstract

High vitamin E supplementation in the diets of streptozocin-induced diabetic rats eliminates accumulation of lipid peroxides in the plasma and the liver, returns the plasma triglycerides toward normal levels, and increases the activity of lipoprotein lipase. Vitamin E has no effect on the levels of insulin or glucose. These findings suggest that vitamin E increases the total hepatic triglyceride lipase activity by increasing the lipoprotein lipase activity possibly by protecting the membrane-bound lipase against peroxidative damage.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Blood Glucose / analysis
  • Diabetes Mellitus, Experimental / enzymology
  • Diabetes Mellitus, Experimental / metabolism*
  • Insulin / blood
  • Lipase / metabolism
  • Lipid Peroxides / blood
  • Lipoprotein Lipase / metabolism*
  • Liver / drug effects
  • Liver / enzymology*
  • Male
  • Rats
  • Rats, Inbred Strains
  • Triglycerides / blood*
  • Vitamin E / pharmacology*

Substances

  • Blood Glucose
  • Insulin
  • Lipid Peroxides
  • Triglycerides
  • Vitamin E
  • Lipase
  • Lipoprotein Lipase