Abstract
The cheR methyltransferase, known to be necessary for the methyl esterification of receptors involved in chemotaxis, is shown to be essential to the synthesis of S-methyl glutathione from glutathione and S-adenosylmethionine in intact Escherichia coli. S-Methyl glutathione is not, however, found to be essential for chemotaxis. It is suggested that the synthesis of S-methyl glutathione may be due to a "parasitic" reaction of glutathione with S-adenosylmethionine bound to the methyltransferase.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Chemotaxis
-
Escherichia coli / enzymology
-
Escherichia coli / metabolism*
-
Escherichia coli / physiology
-
Glutathione / analogs & derivatives*
-
Glutathione / analysis
-
Glutathione / biosynthesis
-
Glutathione / metabolism
-
Methylation
-
Methyltransferases / metabolism*
-
S-Adenosylmethionine / metabolism
Substances
-
S-Adenosylmethionine
-
Methyltransferases
-
chemotaxis methyltransferase
-
Glutathione
-
S-methyl glutathione