Association Between Autoimmune Diseases and Spontaneous Cervicocranial Arterial Dissection

Front Immunol. 2022 Jan 21:12:820039. doi: 10.3389/fimmu.2021.820039. eCollection 2021.


A series of biopsies and reports showed autoimmune diseases might be involved in the process of local inflammation related to spontaneous cervicocranial arterial dissection (SCCAD) occurrence. This retrospective case-control study examined the association between SCCADs and autoimmune diseases in patients and control subjects from 2014 to 2020. SCCAD patients and age/sex-matched control subjects were recruited, and clinical data were collected. SCCAD was confirmed by digital subtraction angiography or high-resolution magnetic resonance imaging. The study included 215 SCCAD patients and 430 control subjects. Totally, 135 (62.8%) of the 215 cases were found SCCAD in the anterior circulation, 26 (12.0%) patients involved multiple vessels. Autoimmune disease occurred in 27 (12.6%) cases with SCCAD and 4 (0.9%) control subjects (p<0.001). A conditional multivariable logistic regression model was used to calculate the odds ratio for SCCAD among patients with a history of autoimmune disease, adjusting for hypertension, diabetes, hyperlipidemia, and smoking. After adjustment, autoimmune diseases were associated with SCCAD (p<0.001). After sub-analysis by a similar modeling strategy, significant associations were still observed in different subgroups, such as female group and male group as well as intramural hematoma (IMH) group and Non-IHM group. The association of SCCAD with autoimmune disease suggested that autoimmune mechanisms may be involved in some etiologies of SCCAD.

Keywords: autoimmune; cervicocranial arterial dissection; inflammatory; inflammatory autoimmune disease; neurological disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aortic Dissection / diagnosis
  • Aortic Dissection / epidemiology*
  • Aortic Dissection / etiology*
  • Autoimmune Diseases / complications*
  • Autoimmune Diseases / diagnosis
  • Autoimmune Diseases / epidemiology*
  • Autoimmunity
  • Biomarkers
  • Case-Control Studies
  • Comorbidity
  • Disease Susceptibility*
  • Female
  • Giant Cell Arteritis / pathology
  • Humans
  • Male
  • Middle Aged
  • Odds Ratio


  • Biomarkers