Limonoids from the fruits of Chisocheton lasiocarpus (Meliaceae)

J Asian Nat Prod Res. 2023 Jan;25(1):36-43. doi: 10.1080/10286020.2022.2032678. Epub 2022 Feb 7.


Two new azadirone-type limonoids, namely lasiocarpine A (1) and lasiocarpine B (2) were isolated from the fruit of Chisocheton lasiocarpus along with three known limonoids (3-5). UV, IR, one- and two- dimensional NMR, and mass spectrometry were used to determine the chemical structure of the isolated compounds. Furthermore, their cytotoxic activity against breast cancer cell line MCF-7 was evaluated using PrestoBlue reagent. From these compounds, lasiocarpine A (1) showed the strongest activity with an IC50 value of 43.38 μM.

Keywords: Chisocheton lasiocarpus; MCF-7 cell line; cytotoxic activity; lasiocarpine; limonoid.

MeSH terms

  • Antineoplastic Agents*
  • Fruit / chemistry
  • Limonins* / chemistry
  • Limonins* / pharmacology
  • Magnetic Resonance Spectroscopy
  • Meliaceae* / chemistry
  • Molecular Structure


  • Limonins
  • Antineoplastic Agents